Although the level p53 is generally known to be regulated at the posttranslational level via ubiquitin-dependent proteasomal degradation pathway, our study showed that such mode is not the primary regulatory mode of p53 diminution during replicative senescence in NHKs (Fig. 3A, B).
Our previous studies have shown the absence of telomerase activity in NHOF, its presence in exponentially replicating NHOK, and its gradual diminution during senescence in NHOK (Kang et al, 1998).
Finally, our hypothesis is strengthened by the diminution of the PdC-Lectin transcript level during stress and during symbiosis breakdown.
Despite the difficulties regarding both immunological and socioeconomic aspects that malaria eradication arouses, promising results have been achieved during last decade, like a diminution of the mortality by 25% between 2000 and 2010 [ 208].
The results are presented in Figure 3, where it can be seen that there is a progressive diminution of the partial pressure of N2 during which the partial pressure of NN increases while the partial pressure of N2 is constant.
Mr. Berg said that donning tefillin -- the sacred assemblage of leather boxes and straps worn during weekday morning prayer -- represents diminution of the desire to receive and a strengthening of the desire to share.
PEG showed lower nanonizing capacity during HPH, but freeze-drying produced further diminution of the particle size.
This protection compensates for the loss of cytoplasmic sperm enzymes that occurs during maturation and transportation processes, resulting in diminution of the spermatozoa's endogenous enzymatic and repair defenses [ 4– 7].
This cyclical pattern does not persist indefinitely: a step-wise diminution of the osmotic pressure differential, because of the solute leakage during burst events, gradually dampens the oscillations ultimately equilibrating the GUV to the residual osmotic differential.
Chromatin diminution is the programmed deletion of DNA from presomatic cell or nuclear lineages during development, producing single organisms that contain two dramatically different nuclear genomes.
