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Sustained-release and controlled-release drug delivery systems can reduce the undesired fluctuations of drug levels, consequently diminishing side effects while improving the therapeutic result of the drug.
Novel DDS aim to target compounds to tumor sides thereby diminishing side effects on healthy tissues.
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In an effort to reduce the BMP-2 dose to avoid or diminish side effects, we investigated whether delivery of BMP-2 using graphene oxide (GO) can reduce the BMP-2 dose for bone regeneration.
One of the main obstacles in developing Kv7 channel active drugs has been to identify compounds that can discriminate between the neuronal subtypes, a feature that could help diminish side effects and increase the potential of drugs for particular indications.
However, social support was not associated with improved survival or diminished side effects from chemotherapy.
Therefore, investigating the peak times of oral mucosa cells could dictate the timing of treatment to diminish side effects.
Techniques to decrease NTCP: optimum timing between radiotherapy and cisplatin administration; more conformal radiotherapy (IMRT); image-guidance during treatment; normal tissue radioprotectors such as amifostine; chronotherapy involving knowledge of normal tissue circadian rhythms, especially of the oral mucosa and bone marrow to diminish side effects of both radiotherapy and chemotherapy.
Delivery of chemotherapeutic agents after encapsulation in nanocarriers such as liposomes diminishes side-effects, as PEGylated nanocarrier pharmacokinetics decrease dosing to healthy tissues and accumulate in tumors due to the enhanced permeability and retention effect.
It may be possible to reap the positive effects of caffeine without the creativity-diminishing side effects, however.
Traditional Chinese medicines have been recognized as a new source of anticancer drugs as new chemotherapy adjuvant by enhancing the efficacy and diminishing the side effects of chemotherapies.
When it is not present at high levels in breast tumors, BCAR4 is normally found only in the human placenta and oocyte, diminishing the side effects of such a therapy [ 93].
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CEO of Professional Science Editing for Scientists @ prosciediting.com