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Diminishing side reactions by advanced surface coatings and treatments may be a feasible solution along such direction.
Sustained-release and controlled-release drug delivery systems can reduce the undesired fluctuations of drug levels, consequently diminishing side effects while improving the therapeutic result of the drug.
While there are numerous engineering reasons, one major driver is the increase of selectivity by diminishing side and follow-up reactions, most often the total oxidation to carbon dioxide, through preventing or at least decreasing hot spot formation.
Novel DDS aim to target compounds to tumor sides thereby diminishing side effects on healthy tissues.
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In an effort to reduce the BMP-2 dose to avoid or diminish side effects, we investigated whether delivery of BMP-2 using graphene oxide (GO) can reduce the BMP-2 dose for bone regeneration.
but didn't find that it "diminishes side one's oblique, charming tour of the popular rhythms of the day".
One of the main obstacles in developing Kv7 channel active drugs has been to identify compounds that can discriminate between the neuronal subtypes, a feature that could help diminish side effects and increase the potential of drugs for particular indications.
However, social support was not associated with improved survival or diminished side effects from chemotherapy.
Therefore, investigating the peak times of oral mucosa cells could dictate the timing of treatment to diminish side effects.
Techniques to decrease NTCP: optimum timing between radiotherapy and cisplatin administration; more conformal radiotherapy (IMRT); image-guidance during treatment; normal tissue radioprotectors such as amifostine; chronotherapy involving knowledge of normal tissue circadian rhythms, especially of the oral mucosa and bone marrow to diminish side effects of both radiotherapy and chemotherapy.
Mechanical hypoaesthesia (loss of touch sensation) was diagnosed when touch sensation on one side was diminished in side to side comparison.
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