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The main exception to this is the liver where treatment with empty liposomes diminished uptake of In-anti-F4/80-A3-1 compared to the control group.
Liposomal doxorubicin (LD), doxorubicin hydrochloride encapsulated in liposomes coated with methoxy polyethylene glycol, has shown diminished uptake by the reticule endothelial system, a longer half-life, a different toxicity profile from that of non-polyethylene glycolylated liposomes, and theoretically increases liposomal deposition in tumour tissue.
The ZnT8-downregulated cells exhibited diminished uptake of exogenous zinc, as determined using the zinc-sensitive reporter dye, zinquin.
The presence of CT166 in EBs and in the host-cell cytosol during the first 60 min p.i. [2] together with the diminished uptake of chlamydiae in CT166 over-expressing HeLa cells further support the assumption that CT166 plays a role during the controlled entry of this pathogen.
Diffused diminished uptake was seen in seven patients.
The lower toxicity might result by diminished uptake into human cells due to modification of side chains.
Similar(47)
This has two desirable haemostatic outcomes: fibrin monomers will polymerise and form clots more rapidly, and two galactose residues can never be exposed diminishing uptake of the protein by the asialoglycoprotein receptor and ramping up concentration at a time of challenge.
Metastases showing a short-term effect (duration of tumor reduction <3 months, n=2) had a slightly diminished FDG uptake, and in progressing metastases (n=3) an enhanced FDG uptake (13±17%) was observed.
AD significantly diminished the uptake of [18F]FDG, but not [11C]acetate in androgen-sensitive PCa [18].
We have reasoned, therefore, that the relative deficiency in energy in rpS6P−/− muscle might reflect impaired insulin signaling, and consequently diminished glucose uptake by this tissue.
Diminished dextran uptake and mannose receptor expression correlated with lupus disease activity.
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