Structural steric hindrance diminishes target accessibility and hence raises the transition state energy of the interacting species.
Industry minister Ian Macfarlane would not have believed his luck when the clean energy council (CEC) buckled to a 20% reduction in the renewable energy target (RET), diminishing the target from 41,000 gigawatt hours of energy to 33,500GWh.
Release of ACh from isolated human placental villi is significantly diminished by targeting OCT3 with antisense strategy (Wessler et al. 2001a).
However, increasing evidence supports the view that mechanisms involved in MDR include decreased drug accumulation in tumor cells, altered intracellular drug distribution, increased detoxification, diminished drug-target interaction, increased DNA repair, altered cell cycle regulation, and uncoupled pathways linking cellular damage with apoptosis [ 14, 15].
But the implication — that systematic account suspensions can reduce the volume of extremist propaganda — is heartening nonetheless, offering a counterweight to the argument that fighting extremist propaganda on mainstream platforms via account suspensions is futile because new accounts can just be recreated (i.e. it's not so futile if you are diminishing your target's vocal chords).
It leaves its target diminished as a human, a lifetime member of a presumptive criminal class.
Nevertheless, the magnitude of translational repression by let-7 is diminished when the target reporter lacks a poly(A) tail.
To diminish off-target effects, we have applied a scaffold hopping strategy replacing the benzoic acid moiety of flufenamic acid with an acidic hydroxyazolecarbonylic scaffold.
Although the concept of dual inhibition is intriguing, selective BRD4 inhibitors are preferred as they may diminish off-target effects and provide more flexibility in anticancer drug combination therapy.
A recent study has shown that the XPO5 genetic defect traps pre-miRNAs in the nucleus of cancer cells, reduces miRNA processing, and diminishes miRNA-target inhibition.
