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The WT 02161A strain possessing the frameshift/truncation mutation in the simA gene also showed significantly diminished survival compared to WT strain K288 by the 18 h time point (P<0.0001) (Fig. 7C).
In fact, disproportionate radiotherapy delays might explain diminished survival rates [ 10].
Thus, a shorter LTL reflects a higher cumulative burden of inflammation and oxidative stress, increased atherosclerotic risk, and diminished survival.
In the general population, short telomere length (TL) in leukocytes is associated with increased risk of atherosclerosis and predicts diminished survival in the elderly (Aviv, 2012).
In RCC patients, KMc showed a significantly diminished survival rate in patients with abnormal baseline β-CTX and in those with higher β-CTX values than ROC-CO.
Especially in more than 30%% of elderly patients (65+) chemotherapies are discontinued within 1 4 months due to persistently high levels of symptoms and functional impairments, leading to significantly diminished survival [ 13].
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In the current study we detected transferred cells surviving and proliferating to 30 days, but the absolute number of recovered cells is small and may reflect a diminishing survival with time.
Overdosing with reactants decreases specificity of treatments by increasing the number of affected oxidants and diminishing survival rates [ 6, 7].
It is known that neuroinflammation based on activation of astrocytes and microglia diminishes survival of motor neurons to exacerbate disease progression of ALS [ 4].
In the OS analysis, we also see a pattern of diminishing survival difference between the two BMI groups >10 years after diagnosis.
Given this fact that (above an optimum level) increased stem cell dose actually decreases survival, one cannot simply assume that the decreased stem cell homing seen following TBI will necessarily diminish survival.
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