Sentence examples for diminished stem from inspiring English sources

A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of aging, and the depletion of stem cell reserves and/or diminished stem cell functions have been postulated to contribute to aging.

Moreover, MSCs with high passage number showed diminished stem cell activation and myocardial protection.

Alongi et al. reported that inflamed pulp tissues contained a population of MSCs with diminished stem cell properties, including reduced osteo-/dentinogenic differentiation [ 4].

Senescence can dampen the repair and regenerative ability of a tissue due to an increased population of growth arrested cells and a diminished stem cell population; and thereby play a hand in tissue ageing.

In terms of decreased CD4 T-cell production, decreased bone marrow clonogenic capability with diminished stem cell precursors contributing to CD4 depletion has been described in three relevant studies [ 3].

For example, the decreased maintenance of telomere length in Ku80 heterozygous mutant mice, which are defective in DNA double-strand-break repair, diminishes stem cell renewal and accelerates muscle aging (Didier et al., 2012).

However, silencing efficiency together with individual siRNA concentrations diminished from stem base to loop side along the length of the duplex.

Syndecan-1 expression diminished, whereas stem cell markers such as SOX2, NANOG, OCT4, and E2F3 increased.

Common features of aging such as decreased wound healing in the skin, decreased immunity, hair greying, and hair loss all result from reduced tissue homeostasis and regeneration with age, due to diminished somatic stem cell function (Sharpless & DePinho, 2007).

However, silencing efficiency together with concentrations of individual lhRNA-derived siRNAs diminished from the stem base (first position) towards the loop side of the hairpin.

In contrast, a recent study found that sodium arsenite diminishes neuronal stem cell differentiation via overactivation of an ERK signaling pathway (Ivanov and Hei 2013).