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Consistently, we demonstrated that this gain-of-function Notch phenotype was a direct consequence of failed scutellar SOP specification; the expression of neuralized-lacZ was diminished specifically in SC SOPs but not in dorsal-central (DC) SOPs where CG32479 was not overexpressed.
This staining was diminished specifically with TRIM3 RNAi constructs and not by other shRNAs, confirming the specificity of the antibody staining (see Figure S1B).
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Mutation of amino acid residues in the membrane spanning region of Vpu specifically diminished its capacity to bind CD317.
Ether phosphatidylcholines and ether phosphatidylethanolamines, that comprise arachidonic (20∶4) and docosapentaenoic (22∶5) fatty acid moieties, were specifically diminished.
Taken together, targeted deletion of LMO4 specifically diminished the generation of selective Bhlhb5+ OFF-cone bipolar cells and GABAergic amacrine cells.
Additional work demonstrated that RNAi-mediated reduction in FLN expression specifically diminished transcription of PEP-dependent genes.
We raised and characterised N- and C-terminal Setd2 antibodies to confirm that Setd2 protein levels were specifically diminished as a result of its mRNA knockdown.
A standardized pomegranate extract (PE) specifically diminished IL-1-induced and MKK3- activated p38α-MAPK isoform and Runx2 (runt-related transcription factor 2) activity.
Similarly, Kasper et al. demonstrated that MSC function is altered and diminished with age, specifically showing lower actin turnover and therefore decreased motility, decreased antioxidant power, decreased responsiveness to chemical and mechanical signaling, and increased senescence (Kasper et al., 2009).
The mechanisms of ketotifen mediated restoration of function are the same mechanisms that resulted in their original alteration, specifically, diminished co-transporter numbers in villus and enhanced affinity for glutamine in crypt cells during chronic intestinal inflammation.
Our hypotheses for this study were that asymmetries in periarticular muscle strength and proprioception, specifically diminished muscle strength and proprioceptive acuity in the contralateral limb to the affected hip, are present early in participants known to be at high risk of developing OA.
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Justyna Jupowicz-Kozak
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