The absence of pain responses in KitW-sh/KitW-sh mice indicates that mast cells are required for histamine-mediated pelvic pain, but KitW-sh/KitW-sh mice reconstituted with HDC−/−bone marrow exhibited diminished, albeit significant, pain.
21, 36, 41, 42 Homozygosity for missense NAGS mutations, depending on the effect of the single amino-acid substitution, may result in either absent NAGS function or diminished but significant residual NAGS activity.
Unfortunately, these encouraging results have been diminished by significant risks of renal failure, thrombotic microangiopathy (TMA) and sinusoidal obstructive syndrome (SOS) observed with the sirolimus and calcineurin inhibitor (CNI) combination in GVHD prophylactic, acute and chronic GVHD treatment trials.
However, adding PCA diminished several significant effects from GLS that were consistent with the AIPL results, including the BTA14 effects for protein yield and the BTA6 effect for somatic cell score (Additional file 11: Figure S7).
Mr. Rivera, a 34-year-old political aide and part-time college professor, defeated Mr. Espada nearly two votes to one in a Democratic primary election that sent a clear message calling for change in Albany, where Mr. Espada's long list of scandals had done little to diminish his significant power.
That technology has been dramatically made over in Vista, however, and if the early reviews are an indication, the built-in search tools in the new operating system could diminish a significant beachhead that Google established on PC users' desktops.
No one is lowering their guard just yet, but the chances are diminishing that significant amounts of oil from the ongoing Deepwater Horizon spill will soon make it to southern Florida.
However, the utility of integration quickly diminishes when significant spectral overlap is present, either in the H or H-[C] NMR spectra, or both.
Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT.
