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Similar to humans, 24 h after treatment with infliximab arthritic mice showed significantly diminished sensitization to noxious stimuli, as has been established by von Frey as well as Hargreaves' tests, which remained at the level of wild-type mice for at least 72 h.
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Ob/ob mice have deficient mesoaccumbens DA signalling activities, including decreased dopamine release in the NAc (nucleus accumbens), diminished locomotor response to amphetamine, as well as lacking locomotor sensitization to amphetamine injection.
Their triglyceride-lowering and HDL-C raising effects lead to decreased systemic availability of fatty acid, diminished fatty acid uptake by muscle with improvement of insulin sensitization and reduced plasma glucose level [ 36- 39].
Their triglyceride-lowering and HDL-cholesterol raising effects lead to decreased systemic availability of fatty acid, diminished fatty acid uptake by muscle with improvement of insulin sensitization and reduced plasma glucose level [ 24- 28].
The use of bezafibrate is associated with triglyceride-lowering and HDL-cholesterol raising effects resulting in decreased systemic availability of fatty acid, diminished of fatty acid uptake by muscle and improvement of insulin sensitization [ 37, 38].
Moreover, anesthesia was maintained with nitrous oxide in both groups, which has been shown to diminish nociception-induced spinal sensitization in rats and to show a preemptive analgesic effect.
The enhanced sensitization effect presumably due to an abnormal arousal modulation reflects abnormal stimulus processing in schizophrenia, i.e. the diminished ability to learn the irrelevance of simple identical stimuli.
The crowds have diminished.
Labour vote diminished.
Civil liberties have diminished.
Water pressure diminished.
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