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Glaucoma can result in a number of vision problems, including diminished sensitivity to contrasts, oversensitivity to light, problems with glare and lessened ability to see fine details.
That history can best be described as a diminished sensitivity to risk, caused by a long run of success.
Furthermore, atria exhibited a diminished sensitivity to the adenosine-induced negative inotropic effect in the presence of the KATPchannel inhibitor glibenclamide, but not the non-specific K+channel inhibitor TEA.
To simulate the effects of diminished sensitivity to high spatial frequencies, we blurred our lexical stimuli to various degrees; at a modest level of blur, the words are blurry but recognizable, and at a greater degree, they become entirely unrecognizable.
We have demonstrated a diminished sensitivity to Cre-mediated recombination in adult hematopoietic cells derived from Z/AP and Z/EG mice.
For example, Her2 overexpression was positively correlated with diminished sensitivity to androgen ablation, increased AR dependent PSA expression, increased AR activation, increased tumor mass and shortened tumor latency [14], [18] [20].
Similar(30)
The diminished heart rate response to isoproterenol in diabetic rabbits may be due to diminished myocardial sensitivity to catecholamines, possibly combined with altered baroreceptor reflexes.
There is no evidence of a protective effect of diminished maternal sensitivity to stress on the fetus.
This is the first report, to the best of our knowledge, suggesting adrenal dysfunction on the basis of diminished adrenal sensitivity to endogenous and exogenous ACTH, as described after etomidate administration [ 16, 19].
Our results refute the impaired metabolism-low endogenous ACTH hypothesis in either the acute or the chronic phase of critical illness to explain fully a low Δ cortisol with exogenous ACTH, by suggesting that relatively low responses to exogenous ACTH are associated with diminished adrenal sensitivity to endogenous ACTH, irrespective of stage of disease.
We propose a distinct mechanism for conferring tolerance to AAV-transduced hepatocytes that relates to diminished sensitivity of the target organ to T cell mediated effects.
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