Sentence examples for diminished responsiveness from inspiring English sources

The exact underlying pathophysiological mechanism to the hyperdynamic state remains unknown but probably represents a multifactorial phenomenon and may involve impaired neurogenic responses, accumulation of vasodilators and diminished responsiveness to a variety of vasoconstrictors [ 31].

Manitz, M. P. et al. Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro.

PBMC obtained from chronically immune activated individuals had a different overall pattern of TLR9 expression, including reduced upregulation of this receptor following additional immune activation, and diminished responsiveness to CpG-DNA stimulation, in comparison to non-activated individuals.

Kat-60L1 mutants exhibit diminished responsiveness to noxious mechanical and thermal stimuli.

Persistent stimulation of the beta 1-adrenergic receptor (beta 1AR) engenders, within minutes, diminished responsiveness of the beta 1 AR/adenylyl cyclase signal transduction system.

Diminished responsiveness (2-log shift in threshold and maximal contraction; P less than 0.001) to PAF was demonstrated in five dogs after 1 10 antigen, compatible with endogenous release of PAF during prior immune challenge in the same animals.

We show that decreasing levels of cellular sterols correlate with diminishing responsiveness to the Hh signal.

Fluoxetine seemed to mediate its beneficial effect by reducing inhibitory interneuron expression in intact premotor cortex rather than through effects on infarct volume or cell death.There is a gradient of diminishing responsiveness to motor training over the first week after stroke.

The dominant-negative receptor approach is expected to diminish responsiveness to all three TGF-β isoforms, and to reduce or eliminate downstream signaling through all Smad transduction components.

These include diminished desire, diminished sexual responsiveness and dyspareunia (recurrent genital pain associated with sexual activity)[ 22, 23].

Loss of desire is associated with, and often a consequence of, diminished sexual responsiveness.