Exact(5)
We have previously shown that P446L-hGKRP, inversely associated with triacylglycerol levels and glucose levels, affects GCK activity in liver through diminished regulation by F6P [ 12].
In contrast to the progressive lengthening of 3′UTRs observed during development and differentiation, the usage of promoter-proximal PASs and therefore diminished regulation via miRNAs or RBPs is linked to proliferation (Elkon et al, 2012; Sandberg et al, 2008).
This is perhaps especially surprising because RNA degradation is likely to play an unusually prominent role in organisms that exhibit diminished regulation of gene expression at the transcriptional level, as is known to be the case for several parasitic protists.
The resulting deficit in the inhibitory effect on NK cells and the following diminished regulation of cytokine amounts may be a good explanation for the exaggerated immune response observed in DBA/2J mice.
We have previously shown that variant P446L-GKRP increases GCK activity as a result of diminished regulation by F6P and have proposed that this results in increased hepatic glycolytic flux and de novo lipogenesis, accounting for the observed associated phenotypes [ 12].
Similar(55)
The goal was to test the hypothesis that the elderly have diminished laryngeal regulation capability, so we investigated phonatory function in the elderly and young using a sound pressure-loading test.
In our studies, α-23 cells transformed with adenovirus that expressed the mutant TRβ from a patient with RTH, Mf-1, showed diminished negative regulation of TSHα gene expression in the presence of T3.
To be fair, since its 2014 "Revolution of Dignity," Ukraine has introduced some reforms: the tax burden was diminished, banking regulations were improved and patrol police reform was launched, among others.
At present congress is debating a law that would diminish environmental regulation for "strategic infrastructure projects in the national interest", including mining.
[N] More specifically, respondents from all three groups expressed concerns with the actions of the Transitional Councils responsible for drafting their respective new regulations: After reviewing the Draft regulation put out by the Transitional council, my support for regulation diminished almost immediately.
[N] After reviewing the Draft regulation put out by the Transitional council, my support for regulation diminished almost immediately.
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