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Exposure of asynchronous cells for 24 h to tamoxifen at 2 μ M (∼GI50 in MCF7 cells) and 8 μ M (∼GI50 in MMU2 and LCC9 cells) (Johnson et al, 2008) reduced cyclin D1 and increased p21Waf1/Cip1 and p27Kip1 levels; consequently, CDK2 activity was diminished, reflected by decreased pRbpThr821 protein levels in parental MCF7 cells.
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And as United States aid levels have diminished — reflecting bipartisan unhappiness with Pakistani policy — aid from the Chinese has increased.
With increased laser exposure time, the intensity of the free CpG band diminished, reflecting a greater amount of chitosan released to condense CpG.
Prada, an Italian luxury fashion group that also owns brands such as Miu Miu and Church's, has become the latest firm to see the country's diminishing appetite reflected in their bottom line.On March 30th Prada announced that profits for 2014 had dropped by 28% from the previous year, to just €451m ($484m).
Similarly, Vaz Fragoso et al. (2008) suggest that a diminished PEF reflects more than chronic lung disease or exposure to smoke or pollution; for example, low PEF may indicate impaired respiratory muscle strength, upper-extremity functional limitations, and poor cognitive function.
Aksum's international trade diminished, a shift reflected in the debasement of the state's coins.
The head of the static division found his power diminished considerably, as reflected in how seriously his subordinates took his efforts at influence (e.g., in programs to increase the profit return from existing volume).
The statistically significant decrease in WRKY70 nucleosomal H3K4me3 in dehydrated wild type cells, in parallel with an increase in cellular PtdIns5P, reflected diminished ATX1 activity.
Hence, we assumed that the weakness displayed by rpS6P−/− mice within a very short exercise time (in some cases within seconds), could have reflected diminished stores of ATP and/or PCr.
Rather, lower health-related quality of life reflected diminished ability to perform ADLs, with increased dependence on others.
Initial improvements in longevity primarily reflected diminished mortality from infections and were largely attributable to improvements in sanitation and nutrition and to the development of effective vaccines.
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