Sentence examples for diminished lifespan from inspiring English sources

The diminished lifespan and higher prevalence of these diseases in HIV-1-infected individuals, in comparison to age-matched uninfected controls, has led to the theory that HIV-1 infection causes accelerated aging in multiple organ systems.

The flies mixed a diet such that they converged upon a nutrient intake trajectory of 1 4 P C, thereby maximizing lifetime egg production and paying the price of a diminished lifespan.

Increased mitochondrial activity plays also a causative role in CR-mediated extension of Drosophila lifespan, since knock-down of either complex I or IV subunits leads to diminished lifespan extension under CR [ 41].

In youth Neuroticism is noted to have a protective effect against mortality since individuals high on this trait are more likely to avoid engaging in high-risk behaviour [ 95]; however, after youth this trait is associated with diminished lifespan [ 96, 97].

Conversely, enhanced β adrenergic signaling results in diminished lifespan, not only in transgenic animal models, for example, overexpression of Gsα (Iwase et al., 1996, 1997), but also in human aging studies with increased β2 adrenergic receptor genotype, where longevity is diminished (Zhao et al., 2012).

Over the past three decades, the prevalence of the common metabolic diseases obesity, type 2 diabetes (T2D), non-alcoholic steatohepatitis (NASH) and atherosclerosis has soared, and these conditions threaten to diminish lifespan for the first time in the modern era (Wild and Byrne, 2005).

Importantly, anergy could diminish the lifespan of anergised B cells if they do not receive other survival signals [ 97– 97].

Additionally, the improvement of cardiac function in young age diminished progressively throughout the lifespan (SFig. 6A and Fig. 7D).

We show that ND2 mutants exhibit phenotypes that resemble symptoms of mitochondrial disease, including shortened lifespan, progressive neurodegeneration, diminished neural mitochondrial membrane potential and lower levels of neural ATP.

We demonstrate here that three strains of dwarf mice (Ames, Snell, and GHR−/−) in which low GH action lead to lifespan extension have diminished density of both AgRP and α‐MSH fibers in the hypothalamus and lower levels of hypothalamic inflammation.

We confirmed this finding and found that the magnitude of hypoxia-induced lifespan extension is significantly diminished in the ubiG strain compared to wt.