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Concurrently, diminished levels of DNA synthesis and depressed S-phase were observed following the treatment regimen of paclitaxel/Pb-TCMC-trastuzumab, occurring at early time points and persisting throughout the 96-h study period.
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Thus, 90CE demonstrates high selectivity toward tumors with diminished levels of O-alkylguanine-DNA alkyltransferase (MGMT), the resistance protein responsible for O-alkylguanine repair.
This results in improved selectivity toward tumors with diminished levels of O-alkylguanine-DNA alkyltransferase (MGMT), the resistance protein responsible for O-alkylguanine repair.
In addition, Treg show diminished levels of CD4 [45] and low levels of CD127 [44].
Individually, TNF-α and EGF diminished levels of aggrecan and type II collagen mRNA.
Similarly, cells derived from SPG11 patients have diminished levels of both proteins.
Additionally, diminished level of consciousness resulted in aspiration and impaired cough due to neurological injury.
Recently, diminished level of MCP-1 was identified in PLCA skin [ 24].
These studies indicate for the first time that the mitochondrial K-ATP channel opener diazoxide improves neurological function after spinal cord ischemia and reperfusion by diminishing levels of reactive oxygen species, decreasing DNA oxidative damage, and inhibiting caspase-dependent and -independent apoptotic pathways while preserving mitochondrial structure.
Considering its role in prosocial behaviors, oxytocin (OT) has been suggested to diminish levels of aggression.
Therefore, spironolactone does appear to diminish serum levels of anti-DNA antibodies, but this does not result in diminished renal ICs.
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