Sentence examples for diminished interaction with from inspiring English sources

Recycling of the variants is reduced, due to their diminished interaction with the FcRn receptor at pH <6.5.

Replacing the piperidine ring by the N,N-diisobutyl residue of piperine diminished interaction with TRPV1 receptors, enhanced potency and efficacy of IGABA modulation, diminished the higher efficacy of piperine on α3-subunit and/or β2/3-subunit containing receptors (compare Fig. 2A and B with Fig. 2D and E) and induced a γ2 subunit dependence (Fig. 2 D).

Consistently, deleting both of the Ig1 and Ig2 domains from Robo2 results in a diminished interaction with Robo1 in vivo and in vitro.

MGAH22, by diminishing interactions with this inhibitory FcγR, would be expected to exhibit additional favorable properties in the presence of mononuclear phagocytic effector cells and potentially further enhanced efficacy against low HER2-expressing tumors or tumors resistant to trastuzumab therapy.

The efficacy of paclitaxel can be attenuated by the overexpression of multidrug efflux transporters, altered metabolism, decreased sensitivity to apoptosis, alterations in microtubule dynamics, diminished interactions of paclitaxel with its cellular target, and genetic polymorphisms [ 1, 2].

As a consequence, diminished interactions of these miRNAs with the mRNAs of vesican, Rb1, and PTEN may occur, which in turn may relieve these mRNAs for translation.

Treatment with ABT-263 abolished or substantially diminished interactions between Bax or Bim with Bcl-2 or Bcl-xL, and very slightly reduced the association of Bax with Bcl-w.

A principle finding was that replacing the piperidine ring by a N,N-diisobutyl-residue did not only diminish interaction with TRPV1 receptors but additionally increased potency and efficacy of GABAA receptor modulation and affected subunit dependency (Figs. 2E, D and Table 1).

This shows that the dynamics in the exosome core are significantly affected or even diminished upon interaction with the cap.

Disruption of a hydrogen bond at position Q739 in M3 severely diminished the interaction with PB3 but still allowed for residual binding.

Furthermore, recent work revealed that 14-3-3 14-3-3 14-3-3h NF-L interactsL-phosphorylation-dependent manner and diminished 14-3-3 interaction with NF-L resulted in the formanion of neurofilament aggregation [ 79].