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We recently reported that cranial bones of Fgfr2C342Y/+ craniosynostotic mice are diminished in density when compared to those of wild type mice, and that cranial bone cells isolated from the mutant mice exhibit inhibited late stage osteoblast differentiation.
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Changing cardiovascular physiology is also reflected in the development of the microcirculation, which exists during the initial days and months following birth as a rich network of microcirculatory capillaries that diminishes in density as the infant grows [ 44].
We recently showed that the frontal cranial bones of Fgfr2C342Y/+ mice are diminished in bone volume and density when compared to those of wild type mice [ 5].
While cell size and basic shape were unchanged, cell population density was greatly diminished in these samples (e.g. Figure 3A), and no matrix of any kind was visible.
Additionally, the total number of synaptic vesicles was diminished in ASMko mice (ASMko 51.4±4.2, wt 71.7±6.6) although their density was not altered with respect to wt synapses (ASMko 295.3±16.95 vesicles/µm2, wt 304.7±44.2 vesicles/µm2), given the smaller size of ASMko presynaptic boutons.
Accordingly, collagen production and fibroblast density in the myocardial granulation tissue were diminished in vivo.
Their utility is diminished in large and complex genomes due to a low gene density.
The weight density of basic sites determined by CO2 TPD drastically diminished in samples treated at 600 °C.
The present study was designed to determine if the activity and density of the ileal bile acid transporter IBAT is diminished in heterozygous and homozygous cftr knockout mice.
Neither area and volume densities, nor absolute values and RAC were significantly diminished in rolipram-treated pups under hyperoxia as compared with hyperoxia alone.
However, the magnitude of the lesions and the number of cankers were significantly diminished in the mutant strain compared to wild-type bacteria, even though the infiltration areas and the bacterial densities were equivalent for both strains.
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