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We recently showed that the frontal cranial bones of Fgfr2C342Y/+ mice are diminished in bone volume and density when compared to those of wild type mice [ 5].
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The primary effect of the tumour is the reduction in bone volume (p<0.01, Figure 7B) and consequent increase in the bone-surface area: bone-volume ratio in tumour-bearing bones (p<0.001, Figure 7C), while the ZOL treatments result in an increase in bone volumes (p<0.001, Figure 7B) and a decrease in bone-surface area: bone-volume ratio (p<0.001, Figure 7C) of tumour-bearing bones.
These results indicated that stimulatory effect of Cthrc1 on bone formation partly prevents reduction in bone volume by ovariectomy.
Despite the increase in bone volume fraction, subchondral bone is hypomineralized due to abnormal bone remodeling [ 6, 7].
Abnormal BMP signaling in neural crest cells was also recently shown to cause diminished cranial bone volume and density in combination with craniosynostosis [ 44].
In addition, we recently reported that Fgfr2C342Y/+ mice on a BALB/c genetic background have diminished cranial bone volume and density when compared to wild type mice [ 5].
Results also show that Crouzon syndrome is associated with significantly diminished appendicular bone volume and density.
While our results also show significantly diminished bone volume and density in the long bones of Fgfr2C342Y mice, future studies are required to definitively establish that Crouzon bone marrow stromal cells are deficient in their ability to differentiate into fully functional osteoblasts and form bone in vivo.
This study also demonstrates that the long bones of Fgfr2C342Y mice have significantly diminished bone volume and density when compared to wild type littermates.
Cortical bone parameters were diminished in long bones of Fgfr2C342Y/+ mice.
But it has lowered and diminished in volume.
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CEO of Professional Science Editing for Scientists @ prosciediting.com