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Subsets of older CF patients exhibit diminished improvement in lung function in response to antimicrobial administration compared with younger CF patients [64], who also typically exhibit better pulmonary function.
Using similar test increased post-surgery POP concentrations were associated with a diminished improvement of liver related parameters [ 37].
The French bariatric surgery cohort observed a positive association between a diminished improvement of liver markers and increased plasma POP concentrations after surgery, but no stratification by sex was performed.
In addition, although it is widely accepted that weight loss associates with metabolic and liver function improvements (Mathurin et al. 2009), we here observed a positive association between a diminished improvement of lipid values and of liver markers and increased POP plasma concentrations.
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However, there are diminishing improvements in net RRR as pre-treatment risk increases.
However, with respect to their general pattern of achievement for the incentivised indicators—high in the first year followed by diminishing improvements in the second and third years the sampled practices followed the national trend.
In vitro kinetics of purified variants showed that the process of directed evolution recovered proteolytic activity by an improvement in both ${k{{{\rm obs1}\hfill \atop 2\hfill}}}$2×10-foldld) and ${k{{{\rm obs2}\hfill \atop 2\hfill}}}$3×10-foldld) and also changed the burst amplitude, with diminishing improvements in later rounds.
30 It has also been reported that moderate to severe Alzheimer's disease pathology in cortical biopsy specimen is associated with worse baseline cognitive performance and diminished postoperative improvement on iNPH symptom severity scales compared to patients lacking pathology.
This added workload is likely to have negatively impacted on the potential for these teams to participate in the RCB activities and thus diminished potential improvements to RCB available through the initiatives.
Although models constructed from greater numbers of regulatory elements generally yielded improved prediction accuracy, this improvement diminished considerably for values of n or m greater than 4.
Diminishing improvements are seen for filters greater than Z=65 and for thicknesses greater than the 500th value layer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com