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Thus, modulating the type I IFN pathway in pulmonary infections caused by non-viral pathogens can lead to both enhanced or diminished host resistance and thus represents a potent immunotherapeutic target.
Cell cycle perturbations may impair leukocyte proliferation, leading to a significantly diminished host response and consequently a more severe infection.
Thus, this protein may modulate Toll/IL-1R signaling, resulting in a diminished host immune response and enhancing viral survival.
Diminished host defense allows progressing postsurgical metastasis or recurrence of the cancer.
It is important to note that the diminished host response to LPS was only observed in the space-flown samples.
It is generally accepted that PPI therapy can alter intestinal microbial profiles by inducing hypochlorhydria resulting in a diminished host defense against certain bacteria [ 25- 28].
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1Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce antitumor activity is not known.
Importantly, the data imply parasite-skin interactions actively diminish host protective responses.
Our findings suggest that, during primary influenza infection, an unabated cell cycle dysregulation in systemic immune cells diminishes host response.
The results obtained show that in both phagocytic and non-phagocytic cells, the process of T. cruzi entry into the host cell is drastically diminished when host cells are treated with dynasore, thus indicating the participation of dynamin in this process.
MyD88-deficient mice displayed a markedly diminished inflammatory host response in the brain, which was characterized by reductions in the expression of cytokines, chemokines and complement factors.
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