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Our results show why the dG- N-AAF lesion manifests a significant propensity to misincorporate dTTP through wobble pairing facilitated by N-clasp flexibility, while the dG- N-B[ a]P adduct imposes diminished flexibility and is bypassed in a nearly error-free manner by Polκ.
However, the connecting and neighboring loops were longer, which may compensate for the diminished flexibility of the second main domain.
This implicates a diminished flexibility to overcome previously learned contingencies.
The resulting diminished flexibility of the subchondral bone can lead to increased pressure applied to the overlying cartilage leading to early-onset osteoarthritis in the long-term [ 25].
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Men tell me they are surprised by the powerful, visceral reactions they have when they first notice their diminishing flexibility, strength and endurance.
This phenomenological observation has led to explore the idea that OCD patients have diminished behavioral flexibility.
This phenomenological observation has led to explore the idea that OCD patients may have diminished behavioral flexibility.
Diminished cognitive flexibility has been noted in a variety of neuropsychiatric disorders such as anorexia nervosa, obsessive compulsive disorder, schizophrenia, autism, and in a subset of people with ADHD.
However, batimastat-treated myotubes showed reduced ability to switch substrate from glucose to palmitate in response to increased substrate delivery (Fig. 5h), indicating diminished metabolic flexibility.
Furthermore, inhibition of α-secretase with batimastat reduced the increase in OCR elicited by palmitate in the presence of glucose, indicating diminished metabolic flexibility.
On the other hand, the primarily polysaccharide moieties (62 64 and 72 ppm) exhibit moderately diminished local flexibility (longer values of T1(C)) for both the native wild-type and FHT-RNAi with respect to wound periderm samples.
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