"Diminished expression of ordinary social graces".
Further, HSC5 and HSC7 show diminished expression of LMP7/tapasin, and PA28α/β, respectively.
Cytosolic LANA directly binds to cGAS, leading to inactivaiton of cGAS and diminished expression of type I IFNs (Zhang et al., 2016).
Some sporadic human cancers also show abnormalities in MMR gene function, typically due to diminished expression of one of the MutL homologs, MLH1.
To the contrary, ERK2 signaling blockage by a MEK inhibitor U012 diminished expression of EMT and CSC markers, implying the potential of targeting this pathway to reduce residual tumor burden, a common cause of ovarian cancer recurrence.
The observation of reduced fetal leukocyte trafficking and chemotaxis is mainly explained by diminished expression of leukocyte adhesion molecules and production of cytokines at this developmental stage [26 28].
As a consequence, monocyte and dendritic cell deactivation with diminished expression of both HLA-DR and co-stimulatory molecules can be observed as an indicator of reduced phagocytosis, antigen presentation, and diminished induction of adaptive immune responses.
In various ICU conditions, measurement of diminished expression of human leukocyte antigen-DR on circulating monocytes (mHLA-DR) by flow cytometry appears to be a reliable marker of acquired immunosuppression.
In various ICU conditions (e.g., trauma, burns, sepsis), measurement of diminished expression of human leukocyte antigen-DR on circulating monocytes (mHLA-DR) by flow cytometry appears to be a reliable marker of acquired immunosuppression [3].
This is consistent with our findings regarding a diminished expression of CD25, a marker associated with proliferation (Figure 3).
As is shown in Figure 4C, treatment of ESFT cells with FSK results in diminished expression of GLI1 transcript.
