Sentence examples for diminished effect of from inspiring English sources

Poor gut absorption of orally administered loop diuretics, decreased delivery to molecular targets, low serum albumin, renal tubular hypertrophy, and circulating organic acids inhibiting the organic anion transporter all lead to a diminished effect of diuretics, resulting in impaired urinary sodium excretion [7].

The diminished effect of morphine was prevented by LNNA, an inhibitor of nNOS function, and naltrindole, a delta-opioid receptor antagonist that also inhibits Akt.

Since OS participants on HT began HT several years before enrolment, a diminished effect of HT with time could explain an OS/RCT difference.

By comparing treated and untreated patients, we were able to delineate the response to tamoxifen irrespective of prognostic features, and a potential agonistic or diminished effect of tamoxifen could be identified.

When administered in combination, the analysis identified a synergistic anti-tumour effect of the two drugs but no diminished effect of capecitabine was supported by the data (λC was 0).

These include a diminished effect of SGLT-2 in the nephron owing to a physiological decline in glomerular filtration rate (GFR) during sympathetic nervous system activation from hypoglycaemia, as well as a putative compensatory increase in hepatic gluconeogenesis.

To check whether the diminished effects of 1,25-dihydroxyvitamin D3 were due to FCS content and not to the optimal effect time we performed the time curve using the maximal concentration of 100 nM over three days at different time intervals (Fig. 1D).

As GWAS are enriched for eQTL, our results imply that GWAS should take into account the diminished effects of loci at older ages.

Diminished effects of higher doses of the extract could result from the interference of constituents that may raise BGL as they get increased in concentration following an increase in dose.

Although additional work in experimental models is warranted to shed further light on the role of this chemokine in mouse steatohepatitis, there is still a strong rationale to investigate approaches that lead to diminished effects of CCL2 in patients with NASH, considering that chemokines and their receptors are also the focus of considerable attention as drug targets [ 38].

Interestingly, coverage analysis of these double-baits indicated a diminished effect on coverage in adjacent regions.