H6PDHKO mice, in which GC sensitivity is greatly diminished, also display improved glucose homeostasis and resist fat accumulation on a high-fat diet (12, 13).
Subsequently, it was shown by experiments that Hog1 phosphorylates Sho1, suggesting that the phosphorylated form of Sho1 displays diminished signaling capacity.
For example, the LRRK2 R1441G mutant mouse displays diminished dopamine release and axonal pathology of nigrostriatal DA projections without neuronal cell loss (Li et al., 2009).
However, Ad.5/3- mda-7 displays diminished antitumour efficacy in several CRC cell lines, which correlates with the expression of K-RAS.
Furthermore, mutation of residues at the top of the interface that pin the E300 and H302 in the flipped-in conformation is more active than wild-type parkin, while mutation of the residues in the basic patch displays diminished activity compared to wild-type, and cannot be stimulated with pUb (Fig 3G).
Finally, despite normal lung volume, Tgfbi-null lungs displayed diminished elastic recoil and gas exchange efficiency.
Processing at high temperature was found to improve the tensile modulus of composites but displayed diminished properties when processed at low processing temperature especially at high fiber content.
Accordingly, in responses to iPTH, T cell null mice display diminished Wnt signaling in preosteoblasts and blunted osteoblastic commitment, proliferation, differentiation, and life span, which result in decreased trabecular bone anabolism and no increase in strength.
When cultured under high carbon conditions, ΔglgC displayed diminished photochemical efficiency, a more reduced NADPH pool, delayed initiation of the Calvin-Benson-Bassham cycle, and impairment of linear and cyclic electron flows.
This is reflected in our study where the reduced mitochondrial activity is present in the septic arms, which also display diminished CSE expression concomitant with nuclear CSE translocation, a reduction of PGC1α and an increase in ADRP, a marker of liver injury [46].
