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The prophylactic administration of an anti-NRP-1 peptide diminished disease severity in mouse CIA.
The addition of Rituximab to the ongoing immunosuppressive therapy of these patients significantly diminished disease activity in most of them.
In IBD animal models, several synthetic, broad spectrum MMP inhibitors significantly diminished disease symptoms compared to placebo-treated controls [ 15].
N-acetylcysteine (NAC), which serves as both a precursor of glutathione and antioxidant in and of itself, also diminished disease activity in SLE patients, through inhibiting mTOR.
The relevance of Tregs in regulation of autoimmunity has been confirmed by extensive research in several mouse models for diabetes and RA in which the transfer of Tregs to sick animals diminished disease [ 17, 18].
Mice that were treated with recombinant mouse netrin-1 for 7 days (1 μg/mouse/day) experienced diminished disease severity as demonstrated by body weight loss, disease activity index, histologic damage and colonic shortening (figure 5A D, respectively) compared with vehicle-treated controls.
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These results indicate that HIF-1α expression is associated with diminished disease-free survival and may play an important role in stromal progression of breast phyllodes tumors.
Our results show that HIF-1α is related to diminished disease-free survival and may play an important role in stromal progression of phyllodes tumors.
Therefore, aggressive immunization using the MB JEV would greatly diminish disease burden.
Due to the complexities of climate change and its impacts on F. hepatica transmission there will be spatio-temporal variation in parasite risk, with some areas experiencing diminishing disease levels.
Regrettably, Shigella relentlessly acquires resistance to antibiotics that were previously effective in diminishing disease severity and duration and pathogen excretion [ 2, 4].
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