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Finally, diminished HspA2 chaperone activity as seen in developmentally immature sperm has been associated with diminished delivery of DNA repair enzymes and thus increased DNA chain breaks and fragmentation (Allen et al., 1996; Dix et al., 1996; Eddy, 1999; Huszar et al., 2000).
The overall effect of these actions is a markedly diminished delivery of iron to the proliferating erythrocyte precursor pool.
These studies reveal the impact (enhanced or diminished delivery) of nanopipet surface charge on delivery of charged molecules by electroosmosis.
Low tidal volumes (VT) and functional residual capacity, high respiratory rates (RR), a shortened particle residence time, and smaller airway diameters account for the diminished delivery of inhaled aerosols to the lower airways in these infants [ 15, 31, 33].
These mechanisms include the diminished delivery of pyruvate into the mitochondrial tricarboxylic acid (TCA) cycle, the inhibition of key mitochondrial enzymes that are involved in either the TCA cycle or the electron transport chain, and the activation of the enzyme PARP-1.
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A diminished oxygen delivery can also result from a reduced oxygen content of the blood.
In addition, tachycardia hypoxemia and diminished oxygen delivery may tip the balance of regional myocardial oxygen consumption over the critical edge.
Meanwhile, the elevation of Epo expression by nitrate in the kidneys, which was exacerbated by environmental hypoxia, is consistent with the notion of enhanced renal hypoxia secondary to diminished oxygen delivery as a result of relative anemia.
This study was undertaken to determine whether the neonatal benefit of a single complete course of antenatal corticosteroids diminishes when delivery is remote from administration (>14 days).
As the condom is held tightly to the skin of the penis, it diminishes the delivery of stimulation through rubbing and friction.
However, perfusion insufficiency downstream of an obstruction caused by vasospasm, thrombus, or surgical ligatures diminishes carrier delivery to ischemic zones.
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CEO of Professional Science Editing for Scientists @ prosciediting.com