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Mutations in Crumbs orthologs in mammals cause progressive retinal degeneration and the retinal pathology reveals diminished contacts between photoreceptors and the OLM (Mehalow et al., 2003; van de Pavert, 2004).
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The way he remembered the events of the Depression is as what we'd call an "elite debacle" – a historical mega-catastrophe caused by hubris, over self-confidence resulting from diminished contact with reality.
Building on the hygiene hypothesis, scientists later proposed that the continued increase in the prevalence of allergic disorders and chronic inflammatory diseases in urban populations in the 21st century was linked to diminished contact with biodiverse environments and the microorganisms they contain.
Both entering into marriage and cohabitation actually results in diminished contact with friends and family.
Interestingly, a recent population based study from Sweden among persons older than 16 years, shows that periods of medication use are associated with diminished contact with the law, and non-use is associated with a return to illegal activities [ 11].
We showed that the activity of AMPK increased with the time of 3D culture (between days 3 and 9 in control conditions), indicating that the centrally located cells of developing spheroids undergo stress related to decreased energy levels due to diminished contact with nutrients and oxygen which are not able to easily penetrate inside the structures.
It should be conceptually distinguished from diminished social contacts, as it does not indicate the quantity but the quality of interaction, which is accentuated by pointing to negative reactions such as being treated with less respect.
They found children later diagnosed with autism initially developed normally but showed diminished eye contact - a hallmark of autism - between two and six months of age.
The high comorbidity with other psychiatric disorders (e.g. conduct disorder) and the resulting deficits in social competences that often go along with a diminished quality of social contacts must be stressed.
Whether such online interactions will lead to diminished face-to-face contact, and whether the increased online connectivity compensates for a hypothetical reduction in face-to-face contact is a question that is yet to be seen.
With diminished numbers come diminished profits.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com