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STD enhancements for phosphotyrosine-containing CCR5 Nt analogs were greatly diminished consistent with earlier findings showing sulfo-tyrosine to be essential for CCR5 Nt binding to gp120.
Knockdown of TRAP1 expresssion using TRAP1 short-hairpin RNAs did not affect responses to 17-AAG, although basal expression levels for several mitochondrial proteins were diminished consistent with the postulated role of TRAP1 as an intramitochondrial chaperone (Figure S3).
The strength of relationships in this study increased between intentions and turnover as the gap between each diminished, consistent with previous findings [ 11].
Levels of phospho-GSK3 β (inactive form) were diminished consistent with increased intracellular active GSK3 β and enhanced degradation of β-catenin seen with Wnt blockade.
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tph-1 mutants showed increased encoding capability in all readouts while daf-7 mutants demonstrated consistently diminished fidelity, consistent with their respective effects on dynamic range and the variability of gene expression.
Fig. 4A shows that the FCCP-uncoupled respiration rates of A549 cybrids were initially high and rather variable, but then diminished with time, consistent with increasing limitation by substrate availability.
In some of the patients with RA the authors were able to directly probe the health of the endothelium by measuring the flow-dependent forearm vasodilatation and found that the RA patients with the minority A1298C allele in MTHFR had diminished vasodilatory responses, consistent with a less healthy vascular endothelium.
CENP-A assembly at the ectopic site induced by tetR-EYFP-hMis18α tethering was diminished by HJURP depletion, consistent with Barnhart et al (2011).
Two human GPI-T signal sequences were also tested and each showed diminished extracellular INV activity, consistent with lower levels of GPI anchoring and species specificity.
The increases in E spl -C transcripts upon cohE spl -Cletranscriptsminished by DAPT treatment, consistent with the idea that increased NICD occuponcohesinributes to the increasedepletioniption.
However, the superoxide production induced by 10 μM ionomycin was not diminished by NOX2 inhibition, consistent with the report that very high calcium elevations can induce neuronal superoxide production by a source other than NOX2.
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