These findings are distinct from those of Thomas et. al. REF. They reported that SR-A deficient mice showed diminished clearance of live S. aureus Cowan 1 strain, as well as decreased survival, after i.p. injection.
The single ΔxprG and double ΔatmA ΔxprG mutant strains were confirmed to have a diminished clearance zone (CIs undetermined).
Genetic deletion of C3 has minimal effect on murine lupus nephritis, probably due to diminished clearance of ICs enhancing immune activation by noncomplement-mediated mechanisms [ 24].
Therefore, we hypothesized that intestinal uptake of p-cresol, in addition to diminished clearance of PCS due to renal failure, is directly associated with adverse outcomes in CKD.
Increased production of triglyceride-rich proteins and the diminished clearance by lipoprotein lipase result in hypertriglyceridemia, which is typically observed in diabetes [ 15].
It should be mentioned that some gliptins, like linagliptin and saxagliptin may be metabolized via the CYP3A4 or CYP3A4/5 pathways, and this could result in a diminished clearance of other drugs using the same pathways.
One small randomized cross-over study (n = 15) and one study comparing 33 patients on predilution CVVH to 15 historical postdilution controls found longer circuit survival with predilution [ 25, 26] at the cost of a diminished clearance [ 26].
This is a quite complex process including increased lactate production, lactate release from the cells and transfer of lactate between different tissues and cells as well as diminished clearance [ 24].
For example, there is decreased CSF production and turnover, diminished clearance of proteins, peptides and other potentially toxic metabolites, altered ion and solute transport, and decreased resistance to oxidative stress [ 1- 3].
Among mice with Pseudomonas aeruginosa pneumonia, those with PAR2 deficiency exhibited diminished clearance of bacteria from the respiratory tract caused by reduced capacity of PAR2-deficient neutrophils to phagocytose and kill Pseudomonas [ 64].
Most probably, the clinical diabetes emerged by the increasing insulin resistance and inhibition of insulin secretion by saquinavir (4, 5) due to its diminished clearance and increased plasma levels.
