Sentence examples for diminished cholesterol from inspiring English sources
As we expected, a diminished cholesterol efflux was observed in the absence of LRP1 due to the low level of ABCA1 expression.
Both gallstone disease and p.D19H of ABCG8 are associated with diminished cholesterol absorption.
Moreover, in the current study a diminished cholesterol absorption ratio was noted in gallstone carriers compared to controls.
In summary, both the presence of gallstones and the ABCG8 polymorphism D19H were related to diminished cholesterol absorption but the polymorphism did not affect ileal expression of ABCG8, suggesting a gain-of-function of the mutated transporter.
As ABCA1 plays a key role in effluxing cholesterol from cells, ABCA1 loss-of-function results in diminished cholesterol removal from peripheral tissues, contributing to excessive accumulation of cholesterol in the body and increased risk of developing atherosclerosis in patients with Tangier disease [ 45- 50].
On the other hand, if the increased propionate level is the major mechanism of action, then perhaps the type of bacteria present in kefir do not preferentially produce propionate over acetate and hence, would not inhibit cholesterol synthesis and lead to diminished circulating cholesterol levels.
In our study, diabetic rats indicated hypercholesterolemia and hypertriglyceridemia and the treatment with SCEE markedly diminished both cholesterol and triglyceride levels.
We previously reported that skin microvascular responses to ACh are mediated through the bioavailability NO and that this is diminished by cholesterol feeding in WT mice [ 25].
Paradoxically, however, we find that SBD trafficking to the lysosome is ultimately diminished by excess cholesterol, in contrast to glycosphingolipids, which accumulate to excess in endolysosomes under similar conditions.
Presence of PVD doubled the risk of PSN (2.31; P = 0.007), whereas an increase of HDL cholesterol diminished the risk (0.21; P < 0.05).
Moreover, gallstone carriers respond to an increased cholesterol load with an elevated biliary cholesterol secretion and exhibit a diminished hepatic de novo cholesterol synthesis [ 3].
