Correspondingly, the G1 checkpoint arrest in these control cells after 5 Gy IR was markedly smaller (Supplementary Figure ESM 3d) compared to U251-NG2 cells, and likewise, diminished G2 checkpoint activation (Supplementary Figure ESM 4).
This third phenotype includes errors in mitotic chromosome segregation, activation of, but failure to sustain, the spindle assembly checkpoint, diminished localisation of spindle checkpoint proteins at kinetochores, and a high rate of failure to complete cytokinesis.
Trade through Van's Gürbulak border checkpoint with neighboring Iran has diminished in recent years due to international sanctions on Iran.
In addition, we investigated several cell cycle-related proteins and found that co-knockdown of hTopBP1 and hMYH significantly diminished cell cycle arrest due to compromised checkpoint kinase 1 (Chk1) activation.
The thud of artillery has diminished around Damascus, and there are few checkpoints in the past couple of weeks, according to recent visitors.
In various other tumor cells, however, checkpoint strength was found to be diminished [5], and recent evidence from mouse models indicate that in cases where such weakening occurs, it can contribute to carcinogenesis ([23] [25] and references in [2]).
A report by the U.S. Travel Association, a travel industry trade group, concludes that security screeners cannot keep up with the deluge and contends that the repercussions range from the serious — diminished security — to the unpleasant — longer lines at the checkpoint.
We also demonstrated that treatment diminished the expression of PD-1, a key immune checkpoint coinhibitory receptor in CD8+ T-cell dendritic cell inT-cell dendritic
14 The legions of American soldiers in Iraq have diminished, and in their place Iraqi soldiers are manning checkpoints and swooping down on suspected criminals.
In Tripoli, more shops and businesses began to open, many rebel checkpoints disappeared from the streets, and celebratory gunfire diminished noticeably.
