Sentence examples for diminished assembly from inspiring English sources

Modeling telomere diseases in iPS cells has also revealed diverse underlying disease mechanisms, including reduced telomerase catalytic activity, diminished assembly of the telomerase holoenzyme and impaired trafficking of the enzyme within the nucleus.

In particular, we noted diminished assembly of the vascular basal lamina, as revealed by determining the overlap between CD31 labeling and labeling for the basement membrane marker collagen IV.

Due to the role of NG2 in pericyte biology, pericyte ensheathment of endothelial cells is diminished during the early stages of tumor vascularization in NG2 null mice, accompanied by reduced pericyte maturation, reduced sprouting of endothelial cells, diminished assembly of the vascular basal lamina, and smaller vessel diameter.

Tumor vessels in the NG2 null mouse are characterized by reduced pericyte coverage of endothelial cells and by diminished assembly of the vascular basement membrane [ 10, 11].

We also found that 15L-5P wasufficientntoto yield a 3Mbp super-scaffold of reasonable quality making it an excellent target sequence mix and depth for a 3Mbp pooled BAC project; however, the addition of 5L + 15P would double the sequencing cost and diminish the assembly quality of such a project, as suggested by the low rank of the 20L-20P assembly in Figure 1.

Binding of the N-terminal 70-kDa fragment of fibronectin to fibroblasts blocks assembly of intact fibronectin [24] and is an accurate indicator of the ability of various manipulations to enhance or diminish fibronectin assembly [11].

GSK3 β diminished the microtubule assembly, as reflected by decreased turbidity.

Both Orc1 E127G and R105Q mutations exhibit reduced chromatin binding of Orc1, diminished pre-RC assembly and impaired activation of replication origins [ 50].

Though its kinetic technical assembly is diminished somewhat, it still splashes and thrashes well enough on the small screen, largely because Blake Lively, as the bloodied boarder stranded agonisingly close to land with a great white circling, gives it some unexpected human nerve.

Remarkably, in softer microwells, cytoskeleton assembly was diminished for the same range of microwell sizes (∼20 kPa; Fig. 3A, S4).

Mutations on the receptor beta subunit designed to disrupt the dodecamer assembly interface diminished the activity of the receptor, providing functional evidence that the higher-order GM-CSF receptor complex is required for siGM-CSF receptor