The het-norm/low FMR1 genotype has in a longitudinal and cross-sectional study been associated with very high ovarian reserve (based on AMH) at young ages, which, however, in the early 30 s, quickly depletes, resulting in rapid AMH declines at relatively young ages and relatively diminished age-dependent ovarian reserve thereafter [12].
Similar white matter compromise has been observed in cocaine dependence, including decreased white matter volume in prefrontal cortex [20]; diminished age-related increase in frontal lobe white matter [21]; and diminished white matter integrity in the inferior frontal lobes [22], [23].
With regard to brain function, Rhesus monkeys subjected to CR showed diminished age-related brain atrophy in key regions of motor and executive functions (Colman et al., 2009).
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The diminishing age of sexual debut for girls observed in this study, reported by many women to be between 12 14 years old, is telling of adolescent girls' increased sexual vulnerability in times of conflict.
Therefore, we selected the brain regions with high versus low MCT8 expression from data set 1 and excluded samples from subjects >60 years of age to diminish age-related effects (data set 4).
Cohort effects may contribute to the observed pattern, but the magnitude of difference in incidence in different birth cohorts would appear to make such effects unlikely candidates as the sole factor for diminishing age-specific LTP.
Fertility starts to decrease on average at about age 30 years and is considerably diminished after age 35.
His quirks have not diminished at age 44.
Yet Flamini's mobility has diminished with age.
Bowie's voice, which is placed high in the mix, is only slightly diminished by age.
