These analogs potently inhibit kinases including Abl and BRAF but have diminished inhibition against some other kinases compared to the parent compound.
The attack on the police station in Falluja highlighted a shift over the last several months in the nature of the war here: While attacks against American soldiers have diminished, those against Iraqi civilians and government officials, who are more easily hit, have risen sharply.
Though vastly diminished, discrimination against Dalits remains a force in everyday life among Sikhs in the countryside, said Surinder Jodhka, a sociologist at the Jawaharlal Nehru University in Delhi.
He will have diminished support against Pouille, who slid 21 aces past Feliciano López and was gifted the result, 6-7, 6-4, 6-4, when the Spaniard double-faulted on match point after two hours of a very tight contest.
Ceftazidime has lost potency due to the emergence of ESBL enzymes and also has diminished activity against P. aeruginosa.
As shown in Figure 5b – d, drug combinations demonstrated diminished synergy against resistant virus strains, in line with in vitro experiments.
11 Alternatively, FLU and LFAmB may be used, but for infection due to C. glabrata an EC is preferred, since the triazoles have diminished activity against this species.
Cell culture studies demonstrate the increased accumulation of lipofuscin in cells undergoing oxidative stress and with increasing replicative age, supporting the concept that senescent cells have diminished defenses against oxidative stress (Sitte et al. 2001).
In plants, it was found that the biosyntheses of the hormones gibberellic acid in Arabidopsis and jasmonic acid in tomato are reduced in csn mutants, leading, for example, to diminished resistance against herbivores and pathogens, whereas the biosynthesis of ascorbic acid (vitamin C) in Arabidopsis is elevated (Dohmann et al. 2010; Hind et al. 2011; Wang et al. 2013).
However, the significant raw difference between different performances (or scores) can be diminished by comparison against control performance (or score) and vice versa.
If journalists, like politicians, emerge from the Leveson inquiry with their collective reputation yet further diminished by the accusations against the few, that assessment will be much harder to reverse.
