Sentence examples for diminished affinity for from inspiring English sources
In this study, it was suggested that dehydration of the active site structure diminished affinity for the ligands.
Mutations in the E3 ligase parkin cause juvenile PD [ 59, 60], and the mechanism was linked to diminished affinity for the 19S particle for at least some of the mutations [ 61].
Intriguingly, engagement of Fyn1's SH2 domain autoinhibits the kinase to an extent greater than that observed for Fyn2 as demonstrated by decreased catalytic activity and diminished affinity for inhibitors that stabilize an active ATP-binding site.
Moreover, Cld-like proteins show a diminished affinity for the prosthetic group.
The diminished affinity for the wild-type enzyme is caused by ∼2.4-fold decrease in kon and a larger (∼16.5-fold) increase in koff.
For example, replacing arginine 59 for alanine in RBD yields a polypeptide with 29-fold diminished affinity for Ras-GTP, and incorporation of a second mutation (N64D) further reduces affinity by a factor of four [ 14, 16].
Aminoglycoside resistance is mediated by enzymatic modification that diminishes affinity of aminoglycosides for the rRNA A-site [ 65].
Substitutions that further diminish affinity for RI (which has a cytosolic concentration of 4 μM) are unlikely to produce a substantial increase in cytotoxic activity.
Additionally, noncleavable linkers afford an opportunity to change the chemical properties of the small molecule to improve potency or diminish affinity for multidrug transporters, thereby improving efficacy.
Changing the medium to 5 mM Tris.HCl and pH 7.4, diminished BSA affinity for the negatively charged bare silica since electrostatic repulsion was increased by increasing negative charge on the protein though maximal adsorption remained approximately the same (Table 2).
Traditional viral and non-viral systems are being engineered to increase their efficiency of vascular cell transduction and diminish their affinity for other cell types through manipulation of vector cell binding and the use of cell-selective promoters.
