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This was assumed to be due to a temporary immune-enhancing effect that later converted to a diminished adaptive immune response.
Upregulation of T cell costimulatory molecules was abrogated in DCs exposed to non-lipidated rP6 and in TLR2−/− DCs exposed to native P6, thereby resulting in diminished adaptive immune responses.
Taking into account previous studies showing a reduced bone adaptation response to mechanical loading in adulthood, these results suggest that the diminished adaptive response is in part due to a reduction in the strains induced within the bone.
A diminished adaptive thermogenesis has indeed been identified as a risk factor for obesity [17].
These findings indicate that a diminished adaptive response to collagen was not responsible for the reduced arthritis.
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Overall, the data imply that each pattern of regulatory innovations yielded diminishing adaptive advantages over time and eventually became exhausted.
In face of the prospect of increased flood risk, the institutional context governing flood management and planning is likely to play a central role in enabling or diminishing adaptive capacity, particularly at the level of municipal authorities who are now in charge of designing local level interventions to reduce vulnerability from present, and ideally, future flood events.
Since cisplatin survival curves are also monotonous when drug resistance diminishes, an adaptive response is more likely than a mutational event to underlie cisplatin-induced resistance.
As a consequence, monocyte and dendritic cell deactivation with diminished expression of both HLA-DR and co-stimulatory molecules can be observed as an indicator of reduced phagocytosis, antigen presentation, and diminished induction of adaptive immune responses.
In addition, it does not diminish the adaptation of ∑ over time, as equilibrium adaptive Monte Carlo sampling does (see [ 45, 46] and references therein).
Hippocampal activation, however, has been shown to diminish in an adaptive manner, as learning reduces the demands related to the binding of higher-order dependencies [7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com