If an enzyme is missing or has diminished activity, the pathway becomes blocked, and the formation of the final product is deficient, resulting in disease.
The dorsal striatum, a region involved in learning from mistakes, also showed diminished activity.
The children subsequently have diminished activity levels but retain the nighttime wakefulness.
Residual wild type protein might be able to exert some function, however with significantly diminished activity due to its reduced abundance.
Microinjection results for the A-series show diminished activity for the AM5, AM6 and, AM8 AM8 constructs and normal activity in the others (Figure 5B).
One group tested mice at 2.5 and 4.5 months and found low normal activity at 2.5 months but significantly diminished activity at 4.5 months.
Of these PDEs, PDE8B and PDE10A have potential in the context of β-cell function, since diminished activity of PDE8B [13] as well as PDE10A inhibition [14] potentiated insulin secretion in response to glucose in rat pancreatic islets.
Furthermore, tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis showed diminished activity and newer findings indicate, that TH gene expression was also reduced after antidepressant treatment [47], [48].
A significantly diminished activity exhibited by the mutants W377A, V209D and D382A (Fig. 6A) is in agreement with the marked influence of the mutations on the structural integrity of the protein as described in the above section.
Some VDAC1-based peptides showed diminished activity.
The EMG revealed diminished activity in 4 of the 6 constipated patients.
