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CD treatment also diminished accumulation of gangliosides, such that GM2 and GM3 storage in the neocortex of treated Npc1−/− mice was nearly absent compared to readily detectable storage in untreated Npc1−/− mice (Fig. 3B; GM3 not shown).
It was shown that platelet depletion diminished accumulation of virus specific Tc-lymphocytes and minimized organ damage.
Indeed, forced expression of miR-221/222 both in myoblasts induced to differentiate and in post-mitotic myocytes caused a diminished accumulation of muscle specific proteins and modification of cellular morphology.
Such mechanism may help explain the diminished accumulation of neutrophils in inflamed tissues observed in studies in vivo with these substances [ 43, 44].
We also show that IPC prevents ischaemia-mediated declines in the 26S ATP-dependant proteasomal activity and that this is associated with diminished accumulation of cellular misfolded proteins.
This was accompanied by a diminished accumulation of starch in stamens of jai1-1 in comparison to WT stamens as visualized by staining of fresh sections.
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Pfa1 (201–767) is sufficient to diminish accumulation of 20S pre-rRNA [ 53].
In cells without tip growth, GFP signal did not accumulate or diminished after accumulation (Supplementary Fig. 4a,b).
Results showed that genistein effectively improved serum and hepatic lipid metabolism and diminished fat accumulation in liver.
Introduction of a dominant-negative Ci-Eph4 to notochord precursors diminished asymmetric accumulation of apicobasal cell polarity markers, leading to defective intercalation.
MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species.
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