However, it is possible that effector CTL remain susceptible to the tolerogenic signals that diminish the function of the tolerant T cells.
Mutations that diminish the function of the extracellular matrix receptor Dystroglycan (DG) result in muscular dystrophies, with associated neuronal migration defects in the brain and mental retardation e.g. Muscle Eye Brain Disease.
This suggests that although the ELN gene tolerates silent polymorphisms, mutations in the locus frequently lead to events that diminish the function of the protein.
We also observed that the therapeutic effects of Pam2IDG are improved by diminishing the function of tumor-associate macrophages (TAMs) and through the use of an IL10 receptor blocking antibody or a Cyclooxygenase 2 (Cox-2) inhibitor.
In humans, it is well accepted that 'vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of immune cells [ 23, 24].
Constant burning of fuels by oxidative process over the life span of an organism is believed to oxidize the components of mitochondrial respiratory system that diminishes the function of various complexes of the mitochondrial ETC (Brand and Nicholls, 2011; Lesnefsky and Hoppel, 2006).
The mechanism by which vitamin D regulates inflammation and immunity appears to be pleiotropic; it controls macrophage and dendritic cell activities and various Toll-like receptor-mediated events in neutrophils [ 39], and it diminishes the function of human dendritic cells by decreasing maturation, antigen presentation and the production of cytokines such as interleukin (IL -12 and IL -12[ 40].
In classical RTK signalling receptors this type of mutant would, depending upon gene dosage, be predicted to exhibit dominant negative properties which diminish the signalling functions of endogenous native receptors in the presence of ligand.
Another attractive explanation for this timing phenomenon could be related to the downregulation of transcriptional repressors such as IRF-8 at the early stage of osteoclastogensis, thereby diminishing the suppressive function of inflammatory factors that utilize these repressors to suppress osteoclastogenesis.
Respiratory insufficiency, the leading cause of death among DMD patients, results from progressive fibrosis that diminishes the contractile function of the respiratory muscles [1] [3].
Furthermore, changes in sleep patterns can last for weeks, Naqvi says, diminishing the restorative function of sleep even after you've stopped drinking.
