Sentence examples for diminish the binding from inspiring English sources

These together may diminish the binding of L77A/L91A to TC-1.

The same mutations diminish the binding of kinesin-1 C-terminal domain to MTs (Seeger and Rice, 2010).

The mutations diminish the binding of antibodies raised against wild-type S protein to virions and subviral particles.

We thus hypothesize that the observed rigidity of the binding sites in the G118V and T109M mutants diminishes the binding of actin and PLP and eventually causes more dramatic conformational changes that increase the propensity of PFN1 for aggregation.

We were able to demonstrate that the mutation p.L95F diminishes the binding of KLHL9 to Cul3.

The study revealed that GADD34 overexpression markedly diminished the binding of TRAF6 to Akt.

(A ) Ca2+ treatment diminishes the binding between RBG-1 and the intracellular domain (C2AB) of SNT-1.

This diminishes the binding affinity of VHL for hydroxylated HIF-α, thereby subtly inhibiting HIF-α degradation and pathologically activating HIF target genes (Ang et al, 2002).

Nevertheless, it is conceivable that the phosphorylation of Ser-577/581 disturbs these interactions, for example, by inducing a conformational change which diminishes the binding of the kinases to B-Myb.

Replacement of guanine to 8-hydroxy-2′-deoxy-guanosine (8-OHdG), one of the major DNA oxidative damage by-products, substantially diminishes the binding of methyl-CpG binding proteins and DNMTs and results in heritable epigenetic changes [ 66- 68].

This is supported by experimental data indicating a basal expression of csgB in mutant strains where the EAL domain was mutated to an AAL domain, thus diminishing the binding affinity of c-di-GMP to YciR [ 7].