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But etherification of this group did not diminish the activity completely.
Vascular smooth muscle cells (SMC) play an integral role in this process by undergoing transdifferentiation to osteoblast-like cells, elaborating calcifying matrix vesicles and secreting factors that diminish the activity of osteoclast-like cells with mineral resorbing capacity.
However, drug leakage in the blood circulation and negative charge on the particle surface might diminish the activity of incorporate drug [14 16].
This hypothesis justified the testing of LNA antisense oligonucleotides as a novel approach to diminish the activity of PCSK9 on LDLR degradation.
115 Beyond its lipase inhibition activity, orlistat reportedly does not significantly diminish the activity of other intestinal enzymes.
The mGluR2/3 receptors function as autoreceptors that, when stimulated by endogenous glutamate, are able to diminish the activity of hyperactive and dysregulated cortical pyramidal neurons [ 5].
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An alternative approach is to identify and develop dietary strategies to selectively enhance the growth and function of endogenous commensals or diminish the activities of detrimental bacteria.
Some data have emerged suggesting that levels of SOD2 have effects on AP-1 and NF- κB activities, in which overexpression experiments diminish the activities of these two important transcription factors (Kiningham and St Clair, 1997; Li et al, 1998a).
Intragastric feeding of SAM in rats diminished the activity of alcohol-activated innate immune pathways (Oliva et al. 2011), highlighting the potential role of SAM in moderating innate immune responses.
Hence, in these studies, natural folates diminished the activity of agents that undergo polyglutamation by suppression of the formation of these active congeners at the level of folylpolyglutamate synthetase.
In the issue of the science magazine Nature that comes out today, Dr. Jain and four colleagues report that in mice with human breast tumors, Herceptin alone diminished the activity of four growth factor genes while encouraging the activity of a gene that inhibits blood vessel growth.
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