We suggest that narrowing of the estimated distribution of replacement rates and accordingly diminished selection with divergence is at least in part due to two limitations of comparative genome analysis.
Drug combinations shorten courses of therapy, reduce toxicities through lower dosage and diminish the selection of resistant mutations.
Deficiency in BIK alone was not able to diminish the selection for loss of p53 function, indicating that loss of BIK cannot compensate for loss of p53.
Study design methods used to diminish potential selection bias included random-digit-dial to identify age-, sex- and county-matched controls from the same population from where the cases were obtained and rapid case ascertainment to identify all incident pancreatic cancer cases diagnosed in six Bay Area counties between 1994 and 1999.
9 The strength of our study lies in the large study population not selected according to medical care, thereby diminishing any selection bias.
In contrast, the high social status of females in bonobo communities is unique to this species of Pan [35], [36] which, coupled to concealed ovulation, could allow greater female choice [37], and this may act as an evolutionary counterstrategy that diminishes sexual selection via sperm competition.
Domestication of pigs has meant confinement and protection against predation, and commercial breeding has mainly focused on fast growth rate and carcass meat content/quality [ 4], thereby diminishing the selection pressure on locomotion traits.
The large sample of routinely collected data diminishes potential selection bias which may result from identification of patients in private practices, hospitals or from clinics specialised in diagnosis and treatment of sexually transmitted diseases, particularly if the identification of patients was based on a convenience sample of private practices or hospitals [ 8, 10, 11].
As will be shown in the 'Simulation Results' section, the SNR gains provided by MMSE diminishes with multiuser selection diversity.
