The exact underlying pathophysiological mechanism to the hyperdynamic state remains unknown but probably represents a multifactorial phenomenon and may involve impaired neurogenic responses, accumulation of vasodilators and diminished responsiveness to a variety of vasoconstrictors [ 31].
PBMC obtained from chronically immune activated individuals had a different overall pattern of TLR9 expression, including reduced upregulation of this receptor following additional immune activation, and diminished responsiveness to CpG-DNA stimulation, in comparison to non-activated individuals.
We assessed damage to worms by looking for apparent changes in behaviour such as lethargy and movement defects or diminished responsiveness to touch, and for reduced fecundity in animals subjected to photobleaching.
However, diminished responsiveness to PPSV23 was observed in patients receiving TAC and concomitant MTX.
76 Asthmatics who smoke often have poor disease control 76 and diminished responsiveness to ICS 54, 77 and systemic corticosteroids.
This condition is characterized by marked sympathetic activation during which the sinus node seems to exhibit diminished responsiveness to neural inputs.
Studies of aging and emotion suggest that older adults show diminished responsiveness to negative information, possibly resulting from increased emotion regulation, but the mechanisms accounting for this effect are uncertain.
The particularly diminished responsiveness observed at week 6 was potentially due to approximately half of the patients not providing a response to the PGAC at day 43 or at the last visit.
Previous investigations of patients with chronic renal failure have also observed reduced concentration of GHBP, 24, 38 which may indicate decreased expression of the GH receptor in target tissues, and hence diminished responsiveness to GH in renal failure.
Similarly, splenocytes that descended from mice that had formerly been infected with AdVαT2ib but not from those infected with AdVGFP displayed diminished responsiveness to TLR2-specific but not to TLR7-specific challenge (Fig. 8D).
