Its phosphorylation by the Akt kinase specifically diminishes its interaction with the capped 5' mRNA terminus reducing its ability to inhibit cap-dependent translation.
An N317T point mutation in XDsh's PDZ-B binding domain (*αXDsh) diminishes its interaction with XDpr1a, whereas a triple mutation in a PDZ domain loop upstream of XDsh's PDZ-B binding domain (272QSNE275 to 272AANA275, ***β-βXDsh) does not [18].
Finally, we show that AGBL1 interacts biochemically with the FCD-associated protein TCF4 and that the mutations found in our cohort of FCD individuals diminish this interaction.
In addition, the chemical modification of SWCNTs, which is able to diminish lateral interaction between SWCNTs and also to improve chemical affinity between SWCNT and matrix, would be a viable approach to help efficient dispersion.
However, reductions in the cytosolic calcium levels diminish the interaction of NR1 subunits with σ1Rs and the presence of Ca2+-CaM, thereby favoring NR1 binding to HINT1 proteins.
The same mutations when introduced in the vertebrate Kinesin-1 domains also diminish the interaction between MT and the C-terminal MT binding motif (Seeger and Rice, 2010).
Modulation of an interaction by modification of multiple residues even allows for rheostatic control of binding strength, where the affinity for an interaction partner is gradually altered by multiple modifications that additively enhance or diminish the interaction.
However mutations of Tyr157, Phe168, Lys221 and Glu223, in the conserved interface, all significantly diminished the interaction, confirming its functional significance.
Once HMGB1 is modified, its interaction with chromatin diminishes.
Technology gives us many benefits but can diminish personal interactions.
