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Indeed, the nuc gene encoding staphylococcal thermonuclease was found to be differentially regulated within a biofilm [39], [40] and was recently shown to diminish adherence of UAMS-1 biofilm under conditions where it is over-produced [41].
As migrating leukocytes contain and release matrix-degrading enzymes, such as Mmp9, that diminish adherence and tissue integrity, they could assist in the reconstruction of the damaged organ by facilitating the rearrangement, proliferation and differentiation of regenerating cells.
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Thoreau, of course, attempted to use his year in the woods to bring to our attention the diminishing adherence to any sort of transcendent human values as we veered into unmitigated materialism in the wake of the industrial revolution.
Premature termination of treatment and diminished adherence to treatment are associated with poorer outcomes.
Mechanisms remain obscure but may include diminished adherence to medical regimens, and self care including healthful diet and exercise.
For the second analysis, to account for participants' possibly diminished adherence to the practices of the lifestyle change intervention over time, we assumed that the effectiveness of the intervention declined by 50% after the third year of the intervention.
26 A qualitative study in Piura and Tumbes in Peru also cited the quick lessening of symptoms and the perceived adverse effects of treatment as the main elements diminishing adherence.
In addition, RS5444 caused dramatic changes in cellular morphology which were associated with increased motility and diminished cellular adherence, but no increase in the ability of such cells to digest and invade Matrigel.
Unlike PAS treatment, the addition of DNase I at all time-points diminished cell adherence (Fig. 1) without having a demonstrable effect on bacterial growth (data not shown).
Additionally, this may lead to either treatment avoidance or diminished treatment adherence in patients with chronic illnesses [ 4, 8, 9].
The binding of AT to glucosaminoglycans diminishes the adherence and migration of leukocytes, reduces platelet aggregation and decreases proinflammatory cytokine production [ 15, 16].
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