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In general, and in line with our hypothesis, lower OPQoL-Brief, EQ-5D-3 L and ASCOT mean utilities/summary scores were associated with correspondingly increasing levels of severity on the dimensions of comparator instruments.
Further, we postulated that lower OPQoL-Brief, EQ-5D-3 L and ASCOT mean utilities/summary scores respectively would be associated with correspondingly increasing levels of severity on the dimensions of comparator instruments.
Table 2 also shows that in general, higher correlations were evident between dimensions of particular instruments and utilities/summary scores of comparator instruments than those observed between individual dimensions of comparator instruments.
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Tables 3, 4 and 5 present the distribution of EQ-5D-3 L, ASCOT and OPQoL-Brief utilities/summary scores across all dimension levels of comparator instruments.
We also examined the distribution of mean EQ-5D-3 L, ASCOT and OPQoL-Brief utilities/summary scores across all dimension levels of comparator instruments.
The convergent validity of the EQ-5D-3 L, ASCOT and OPQoL-Brief utilities or summary scores was explored using scatter plots and an assessment of the level of association (Spearman's correlation) between individual dimensions from each of the three instruments and between these dimensions and utilities/summary scores of comparator instruments.
The output of comparator is the desired PWM signal.
In contrast, the perturbation score we applied in the present study is independent of comparator data.
The search was not limited to one kind of comparator.
The specificity of clinical questions is gauged by explicit descriptions of four dimensions: subjects, interventions, comparators and outcomes of interest.
The relationships between individual dimensions of all instruments and between individual dimensions of one instrument relative to utilities/summary scores for each of the comparator instruments are summarised in Table 2.
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