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Future developments in diagnostic imaging may provide improved and more specific methods of analysing skeletal lesions, including three-dimensional methods such as SPECT/CT and PET/CT.

It may be necessary to use three-dimensional methods such as pharmacophores or docking to understand why such compounds with strong similarity do not cross-react [ 17, 53, 71].

Braque rejected the spatial conventions traditionally used to create volume and depth on the two-dimensional surface, methods such as linear perspective and the classical framing devices as used in Romantic landscape compositions.

High-resolution quadrupolar spectra can be obtained with two-dimensional (2D) methods such as multiple-quantum MAS (MQMAS) [15].

Thus, three-dimensional imaging methods, such as peripheral quantitative computed tomography (pQCT), allow a selective assessment of both trabecular and cortical bone and also estimate bone strength [ 16].

Images captured by two-dimensional (2D) methods, such as radiography, provide only a projection of bone shape and do not provide a complete picture of the patient's anatomy.

An important characteristic of linear dimensionality reduction methods such as PCA is the intuitive interpretation of components in the low-dimensional space in terms of the original dimensions.

DNA nanotechnology is a rapidly progressing field owing to the ease of producing two- and three-dimensional nanostructures through methods such as DNA origami.

To obtain higher peak capacities, comprehensive two-dimensional (2D) separation methods, such as time-based (t LC ×  t LC, using a combination of columns) and spatial (x LC ×  x LC, using a flat separation bed) have been developed.

One of the major goals of three-dimensional (3D) structure prediction methods, such as comparative modeling, threading and ab initio folding, is to elucidate function from a 3D structure.

Non-polyacrylamide gel electrophoresis (PAGE -based analyses are also addressed; however, sePAGE -basedthods such analysesimensionareliquid chromalsoraddressed specific advantages over thowever approach.

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