If, as we hypothesized, the cone dim flash response originates in coupled rods, while the bright flash response originates in both photoreceptors, they should have a different apparent reversal potential (assuming the actual reversal potential EOS in rods and cones to be the same; EOS ≈ 0 mV; Luo et al., 2008).
While brightb flash responses reversed polarity, dim flash responses became smaller but did not reverse.
This is a different kind of poetry performance rather than the lone, solemn figure of the poet standing on stage, a whole ambience has been created with a canopy of interactive light bulbs that glow and dim in response to the words.
Thus, although band pass filtering by Ih reduces dim flash response amplitude, this is more than compensated by a sharpening of its time course.
The time course of recovery of the dim flash response after the bright flash is comparable to that of rods.
All three cones expressed the same time-dependent increase in coupling to rods observed in perforated patch recordings: increased dim flash response and bright flash plateau amplitudes.
This similarity in the time course of recovery after the bright flash emerges from comparing graphs of normalized dim flash response amplitudes during the kinetics protocol in rods and cones.
(A )–(C ) Example data from a single cell showing gain of the dim flash response (A ), noise (B ), and threshold (C ) as a function of background (see 'Materials and methods').
In one of these cones, we tested the effect of the GJ blocker MFA (100 µM): both dim flash responses and plateaus following the brighta flash were abolished, leaving behind a fast response to the brighta flash.
