Liver injury in the remaining 85 cases was caused primarily by SOS (n=46), hypoxic hepatitis (n=33), viral infection (n=4) and DILI (n=2) (Table 2).
Different DILI phenotypes should be referenced using appropriate corresponding descriptors, as listed in Table 1.
The diagnostic classification used (Supporting Table 2) was based on published descriptions of pathologic changes in DILI.
A role for HLA in reactions to drugs other than those listed in Table 1 seems less likely in view of a recent GWA covering DILI due to a wide range of drugs, which failed to show any signal for the HLA region when cases due to drugs known to show a HLA association were excluded [ 18].
To analyze the world distribution of selected alleles associated with DILI, we compared their frequencies with global frequencies in populations submitted to AFND grouped by ethnicity (Table S4a in Additional file 1) or geographic region (Table S4b in Additional file 1).
From September 2004 through October 2010, 249 patients with suspected DILI underwent a liver biopsy that was made available, reviewed centrally, and entered into the DILIN Prospective Study database (Table 1).
Dili is the capital and largest city.
But back in 1999, Dili was devastated.
Dili Babu was dying of AIDS.
Dili, a ramshackle seaside city, remained calm.
